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刘振洋教授:2023 ESMO WCGIC精彩回顾,胃癌靶向治疗迎来新突破

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湖南省肿瘤医院消化泌尿内一科主任

主任医师,医学博士,博士后

湖南省医学会消化肿瘤内科学组组长

湖南省抗癌协会肿瘤靶向治疗专委会主任委员

湖南省抗癌协会大肠癌专委会副主任委员

湖南省抗癌协会家族遗传性肿瘤专委会副主任委员

湖南省医促会恶性肿瘤精准与综合诊疗专委会副主任委员

[2]L. Shen, D. Liu, N. Li,et al. Osemitamab in combination with capecitabine and oxaliplatin (CAPOX) as a first line treatment of advanced G/GEJ cancer: Updated data of cohort C from a phase I/IIa, multi-center study (TranStar102/TST001-1002). 2023 ESMO WCGIC. Abstract PD-7.[3]Z. Wainberg, Y. Kang, K. Lee, et al. Bemarituzumab for treatment of previously untreated advanced and/or metastatic gastric and gastroesophageal cancer (GC): Final analysis of a randomized phase 2 trial (FIGHT). 2023 ESMO WCGIC. Abstract SO-11.[4]T. Satoh, P. Barthélémy, L. Nogova, et al. Phase 2 Study of Futibatinib in Patients With Specific FGFR Aberrations: Activity in Patients With Gastric or Gastroesophageal Junction Cancer Harboring FGFR2 Amplification. 2023 ESMO WCGIC. Abstract SO-10.[5]Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010 Aug 28;376(9742):687-97.[6]Hofheinz R , Hegewischbecker S , Thusspatience P C , et al. HER-FLOT: Trastuzumab in combination with FLOT as perioperative treatment for patients with HER2-positive locally advanced esophagogastric adenocarcinoma: A phase II trial of the AIO Gastric Cancer Study Group.2014 ASCO. Abstract 4073.[7]Shitara K, Lordick F, Bang YJ, et al. Zolbetuximab + mFOLFOX6 as first-line (1L) treatment for patients (pts) with claudin-18.2+ (CLDN18.2+) / HER2? locally advanced (LA) unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma: Primary results from phase 3 SPOTLIGHT study. 2023 ASCO GI. Abstract LBA292.[8]Xu Rh, Shitara K, Ajani JA, Zolbetuximab + CAPOX in 1L claudin-18.2+ (CLDN18.2+)/HER2? locally advanced (LA) or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma: Primary phase 3 results from GLOW. 2023 ASCO GI. Abstract 405736.[9]Kohei Shitara, Rui-Hua Xu, Diarmuid Martin Moran, et al. Global prevalence of CLDN18.2 in patients with locally advanced (LA) unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma: Biomarker analysis of two zolbetuximab phase 3 studies (SPOTLIGHT and GLOW). 2023 ASCO. Abstract 4035.本材料由阿斯利康提供,仅供医疗卫生专业人士进行医学科学交流,不用于推广目的审批编号:CN-120160 过期日期:2024-2-9

* 此文仅用于向医学人士提供科学信息,不代表本平台观点

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